Siberian Federal University

In this research, the influence of inlet temperature, drying gas flow rate, polymer solution feed rate, and polymer solution concentration, both individually and in interaction, on the diameter and zeta potential of poly(3-hydroxybutyrate- co-3-hydroxyvalerate) microparticles produced via the spray drying technique was evaluated. It was determined that particle diameter is predominantly influenced by polymer solution concentration. As a result, the optimal parameters for obtaining microparticles with the smallest diameter and satisfactory zeta potentials were found to be: inlet temperature 100 ºC, drying gas flow rate 35 m3/h, polymer solution feed rate 7.5 ml/min, and polymer concentration 0.1 %. This study demonstrates the applicability of response surface methodology based on a Box- Behnken design to determine the optimal conditions for obtaining microparticles with desired characteristics