Journal of Siberian Federal University. Biology / Synthesis and Study of the Properties of Amphiphilic Poly-N-Vinylpyrrolidone with Terminal Thioalkyl Groups

Full text (.pdf)
Issue
Journal of Siberian Federal University. Biology. 2019 12 (3)
Authors
Shtilman, Mikhail I.; Kuskov, Andrey N.; Kulikov, Pavel P.; Luss, Anna L.; Goryachaya, Anastasia V.; Dzhedzheya, Vazha T.; Tsatsakis, Aristidis M.
Contact information
Shtilman, Mikhail I.: D.I. Mendeleyev University of Chemical Technology of Russia 9 Miusskaya sq., Moscow, 125047, Russia; shtilmanm@yandex; ORCID: 0000-0001-9219-5746; Kuskov, Andrey N.: D.I. Mendeleyev University of Chemical Technology of Russia 9 Miusskaya sq., Moscow, 125047, Russia; ORCID: 0000-0001-8140-2754; Kulikov, Pavel P.: D.I. Mendeleyev University of Chemical Technology of Russia 9 Miusskaya sq., Moscow, 125047, Russia; ORCID: 0000-0001-5221-7613; Luss, Anna L.: D.I. Mendeleyev University of Chemical Technology of Russia 9 Miusskaya sq., Moscow, 125047, Russia; ORCID: 0000-0001-8539-0252; Goryachaya, Anastasia V.: D.I. Mendeleyev University of Chemical Technology of Russia 9 Miusskaya sq., Moscow, 125047, Russia; Dzhedzheya, Vazha T.: University of Crete Voutes University Campus, Heraklion, Crete, GR-70013, Greece; Tsatsakis, Aristidis M.: University of Crete Voutes University Campus, Heraklion, Crete, GR-70013, Greece; ORCID: 0000-0003-3824-2462
Keywords
amphiphilic polymer; copolymers of N-vinylpyrrolidone; micelle; polymeric nanoparticle; polymeric surfactants
Abstract

Poly-N-vinylpyrrolidone-based amphiphilic polymers, which can be used as drug carriers, were prepared by radical polymerization with a thiol-type chain transfer agent. The polymers did not contain sequences of hydrophilic and hydrophobic fragments in the main chain. Molecules contained only one hydrophilic and one hydrophobic fragment linked by a covalent bond. This facilitated the self-organization of macromolecules into micelles in aqueous media. The critical micelle concentration and its dependence on the molecular weight of the diblock copolymers and the length of the hydrophobic radical were determined

Pages
258-265
DOI
10.17516/1997-1389-0300
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/125597

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