Journal of Siberian Federal University. Chemistry / On the Study of Sorption in the Chiral Separation of the Enantiomers of Salbutamol and Salmeterol by Supercritical Fluid Chromatography

Full text (.pdf)
Issue
Journal of Siberian Federal University. Chemistry. 2019 12 (3)
Authors
Mikushina, Irina V.; Bazarnova, Natalya G.; Parenago, Olga O.; Gensh, Konstantin V.
Contact information
Mikushina, Irina V.: Altay State University 61 Lenin, Barnaul, 656049, Russia; ; Bazarnova, Natalya G.: Altay State University 61 Lenin, Barnaul, 656049, Russia; Parenago, Olga O.: Institute of General and Inorganic Chemistry N.S. Kurnakova 31 Leninsky Prospect, Moscow,119071, Russia; Gensh, Konstantin V.: Altay State University 61 Lenin, Barnaul, 656049, Russia
Keywords
enantiomers; supercritical fluid chromatography; chiral separation; sorption mechanism; salbutamol; salmeterol
Abstract

The studied conditions of supercritical fluid chiral chromatography of salbutamol and salbutamol sulfate allowed to assumethe possibility of ionic interactions in the process of separation of enantiomers. It is shown that the structure of the hydrocarbon radical of 1- (4-hydroxy-3- (hydroxymethyl) phenyl) -2-aminoethanol associated with the chiral fragment, and, consequently, the physicochemical characteristics of the substance molecule, such as the number of hydrogen donors and acceptors polar surface, significantly affect the ability to communicate with the sorbent selectors under conditions of supercritical fluid chromatography

Pages
310-318
DOI
10.17516/1998-2836-0128
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/125616