Journal of Siberian Federal University. Biology / Detection of the State of Thrombotic Readiness in Rats under One-Time Suprathreshold Physical Activity of Various Durations by Means of Thromboelastography

Full text (.pdf)
Issue
Journal of Siberian Federal University. Biology: 2019, Vol. 12, Issue 4
Authors
Blazhko, Alexander A.; Shakhmatov, Igor I.; Kovalev, Igor V.; Kiselev, Valeriy I.; Bondarchuk, Yuliya A.; Ulitina, Oksana M.; Alekseyeva, Olga V.
Contact information
Blazhko, Alexander A.: aAltai State Medical University of the Ministry of Health of the Russian Federation 40 Lenin, Barnaul, 656038, Russia; ; ORCID: 0000-0003-2578-6858; Shakhmatov, Igor I.: Altai State Medical University of the Ministry of Health of the Russian Federation 40 Lenin, Barnaul, 656038, Russia; Research Institute of Physiology and Fundamental Medicine of SB RAS 4 Timakov Str., Novosibirsk, 630117, Russia; ORCID: 0000-0002-0979-8560; Kovalev, Igor V.: Altai State Medical University of the Ministry of Health of the Russian Federation 40 Lenin, Barnaul, 656038, Russia; Research Institute of Physiology and Fundamental Medicine of SB RAS 4 Timakov Str., Novosibirsk, 630117, Russia; Kiselev, Valeriy I.: Altai State Medical University of the Ministry of Health of the Russian Federation 40 Lenin, Barnaul, 656038, Russia; Research Institute of Physiology and Fundamental Medicine of SB RAS 4 Timakov Str., Novosibirsk, 630117, Russia; Bondarchuk, Yuliya A.: Altai State Medical University of the Ministry of Health of the Russian Federation 40 Lenin, Barnaul, 656038, Russia; Research Institute of Physiology and Fundamental Medicine of SB RAS 4 Timakov Str., Novosibirsk, 630117, Russia; ORCID: 0000-0002-2661-5965; Ulitina, Oksana M.: Altai State Medical University of the Ministry of Health of the Russian Federation 40 Lenin, Barnaul, 656038, Russia; Research Institute of Physiology and Fundamental Medicine of SB RAS 4 Timakov Str., Novosibirsk, 630117, Russia; Alekseyeva, Olga V.: Altai State Medical University of the Ministry of Health of the Russian Federation 40 Lenin, Barnaul, 656038, Russia
Keywords
physical activity; thromboelastography; thrombotic state
Abstract

Suprathreshold physical activity causing distress in the organism can lead to the damage of various organs and systems including the hemostatic system. A modern integrated method of the hemostatic system assessment is thromboelastography. The purpose of the present study was to evaluate the state of the hemostatic system under one-time suprathreshold physical activity of various durations by means of thromboelastography. Experimental groups of rats were exposed to 4-hour and 8-hour physical activities in the form of forced running on a moving platform with the speed of 6-8 m/min. Immediately after the one-time physical activity, blood samples taken from rats were examined using the thrombelastograph in the Natem mode for 35 minutes. The 4-hour physical activity caused a reduction in coagulation time (CT) and an increase in the alpha angle and the maximum clot firmness (MCF). After the 8-hour activity, the thrombelastograph registered a reduction in coagulation time (CT), an increase in the alpha angle, a decrease in the clot formation time (CFT), a decrease in the maximum clot firmness (MCF), and a reduction in the maximum clot lysis (ML). The 4-hour physical activity resulted in partial activation of the hemostatic system without changing the fibrinolytic activity of blood plasm. The changes revealed in thromboelastography parameters indicate a high risk of the development of thrombotic readiness. The 8-hour physical activity causes a shift of the hemostatic system parameters in rats towards the increased clot formation: hypercoagulation, fibrinogen and platelet consumption, inhibition of fibrinolysis. The combination of changes in thromboelastogram parameters is indicative of the development of thrombotic readiness

Pages
460-469
DOI
10.17516/1997-1389-0312
Paper at repository of SibFU
http://elib.sfu-kras.ru/handle/2311/128441

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