- Issue
- Journal of Siberian Federal University. Biology. 2014 7 (2)
- Authors
- Shishatskaya, Ekaterina I.
- Contact information
- Shishatskaya, Ekaterina I.:Siberian Federal University 79 Svobodny, Krasnoyarsk, 660041, Russia; Institute of Biophysics SB RAS 50/50 Akademgorodok, Krasnoyarsk, 660036, Russia
- Keywords
- drug delivery systems; polyhydroxyalkanoates; spray drying; microparticles; D-optimal design
- Abstract
The possibility of using the spray drying method for the construction of poly-3-hydroxybutyrate (P3HB) based microparticles was studied. The dependence of characteristics of microparticles (yield, average diameter, zeta-potential) from processing parameters (temperature at the inlet of the system, the feed rate of polymer solution and concentration of the polymer solution) was found. It is shown that zeta potential of microparticles was influenced by concentration of the polymer solution, and the average diameter was determined by temperature of the inlet. Also, conditions of obtaining P3HB microparticles were optimized to minimize polymer loss (approximately 10 %)
- Pages
- 195-208
- Paper at repository of SibFU
- https://elib.sfu-kras.ru/handle/2311/13406
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).