- Issue
- Journal of Siberian Federal University. Chemistry. 2020 13 (4)
- Authors
- Sursyakova, Viktoria V.; Levdansky, Vladimir A.; Rubaylo, Anatoly I.
- Contact information
- Sursyakova, Viktoria V.: Institute of Chemistry and Chemical Technology SB RAS FRC “Krasnoyarsk Science Center SB RAS” Krasnoyarsk, Russian Federation; viktoria_vs@list.ru; Levdansky, Vladimir A.: Institute of Chemistry and Chemical Technology SB RAS FRC “Krasnoyarsk Scientific Center SB RAS” Krasnoyarsk, Russian Federation; Rubaylo, Anatoly I.: Institute of Chemistry and Chemical Technology SB RAS FRC «Krasnoyarsk Science Center SB RAS» Krasnoyarsk, Russian Federation
- Keywords
- drug delivery; host-guest complexes; capillary electrophoresis; binding constants; inclusion complexes
- Abstract
Inclusion complexes of ester betulin derivatives (pentacyclic lupane triterpenoids) with β-cyclodextrin (β-CD) were studied by affinity capillary electrophoresis. Stability constants were calculated from dependencies of viscosity-corrected effective electrophoretic mobilities on β-CD concentration (0-10 mM) in background electrolytes using nonlinear regression fitting. Logarithms of stability constants at 25 °C for 1:1 and 1:2 β-CD complexes of betulin 3,28-diphthalate, betulin 3,28-disuccinate and betulin 3,28-disulfate (95 % confidence interval) are 4.25 (4.16-4.32) and 7.27 (6.73-7.50), 4.38 (4.26-4.48) and 7.58 (6.90-7.84), 4.04 (4.00-4.08) and 5.91 (4.60-6.20), respectively
- Pages
- 534–541
- DOI
- 10.17516/1998-2836-0203
- Paper at repository of SibFU
- https://elib.sfu-kras.ru/handle/2311/137877
Journal of Siberian Federal University. Chemistry / Determining Stability Constants of Complexes Between Ester Betulin Derivatives and β-Cyclodextrin by Affinity Capillary Electrophoresis
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