Journal of Siberian Federal University. Chemistry / Determining Stability Constants of Complexes Between Ester Betulin Derivatives and β-Cyclodextrin by Affinity Capillary Electrophoresis

Full text (.pdf)
Issue
Journal of Siberian Federal University. Chemistry. 2020 13 (4)
Authors
Sursyakova, Viktoria V.; Levdansky, Vladimir A.; Rubaylo, Anatoly I.
Contact information
Sursyakova, Viktoria V.: Institute of Chemistry and Chemical Technology SB RAS FRC “Krasnoyarsk Science Center SB RAS” Krasnoyarsk, Russian Federation; ; Levdansky, Vladimir A.: Institute of Chemistry and Chemical Technology SB RAS FRC “Krasnoyarsk Scientific Center SB RAS” Krasnoyarsk, Russian Federation; Rubaylo, Anatoly I.: Institute of Chemistry and Chemical Technology SB RAS FRC «Krasnoyarsk Science Center SB RAS» Krasnoyarsk, Russian Federation
Keywords
drug delivery; host-guest complexes; capillary electrophoresis; binding constants; inclusion complexes
Abstract

Inclusion complexes of ester betulin derivatives (pentacyclic lupane triterpenoids) with β-cyclodextrin (β-CD) were studied by affinity capillary electrophoresis. Stability constants were calculated from dependencies of viscosity-corrected effective electrophoretic mobilities on β-CD concentration (0-10 mM) in background electrolytes using nonlinear regression fitting. Logarithms of stability constants at 25 °C for 1:1 and 1:2 β-CD complexes of betulin 3,28-diphthalate, betulin 3,28-disuccinate and betulin 3,28-disulfate (95 % confidence interval) are 4.25 (4.16-4.32) and 7.27 (6.73-7.50), 4.38 (4.26-4.48) and 7.58 (6.90-7.84), 4.04 (4.00-4.08) and 5.91 (4.60-6.20), respectively

Pages
534–541
DOI
10.17516/1998-2836-0203
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/137877