Journal of Siberian Federal University. Biology / Treatment of Non-Healing Trophic Ulcers in Patients with Chronic Venous Insufficiency Using Wound Coatings Based on Bacterial Cellulose Loaded with Silver Nanoparticles

Full text (.pdf)
Issue
Journal of Siberian Federal University. Biology. 2021 14 (4)
Authors
.Vinnik, Yuri S.; Solovyeva, Natalia S.; Zuev, Andrey P.; Polezhaev, Leonid A.
Contact information
Vinnik, Yuri S.: Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk, Russian Federation; ORCID: 0000-0002-8995-2862; Solovyeva, Natalia S.: Voino-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk, Russian Federation; Zuev, Andrey P.: Voino-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk, Russian Federation; Polezhaev, Leonid A.: Voino-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk, Russian Federation
Keywords
wound coating; trophic ulcer; cellulose; nanosilver
Abstract

Chronic venous insufficiency is a common condition that affects people of different ages. Trophic ulcers are a complication of venous insufficiency which is difficult to treat. Therefore, development of new, combined methods of treatment using coatings that have both antibacterial and wound healing properties is a topical issue. The article presents a comparative analysis of clinical trials of wound coatings based on bacterial cellulose (experimental group 1), cellulose loaded with silver (experimental group 2), and «Hydrocall» (control group) in treatment of trophic ulcers in patients with chronic venous insufficiency. Application of all types of wound coatings demonstrated a positive dynamics of healing. Complete epithelialization was observed in experimental group 2 by the 42nd day, whereas in patients of the control group, epithelialisation was not complete by the 45th day. Thus, application of wound coatings based on cellulose loaded with silver shortened the epithelialisation process and trophic ulcers healing, which justifies to their efficiency and practicality

Pages
526–532
DOI
10.17516/1997-1389-0369
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/145139

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