- Issue
- Journal of Siberian Federal University. Chemistry. 2022 15 (3)
- Authors
- Mikhailenko, Mikhail A.; Shakhtshneider, Tatyana P.; Antonov, Il’ya M.; Myz, Svetlana A.; Kuznetsova, Svetlana A.; Bryazgin, Alexandr A.
- Contact information
- Mikhailenko, Mikhail A.: Institute of Solid State Chemistry and Mechanochemistry SB RAS Novosibirsk, Russian Federation; mikhailenko@solid.nsc.ru; Shakhtshneider, Tatyana P.: Institute of Solid State Chemistry and Mechanochemistry SB RAS Novosibirsk, Russian Federation; Antonov, Il’ya M.: Institute of Solid State Chemistry and Mechanochemistry SB RAS Novosibirsk, Russian Federation; Myz, Svetlana A.: Institute of Solid State Chemistry and Mechanochemistry SB RAS Novosibirsk, Russian Federation; Kuznetsova, Svetlana A.: Institute of Chemistry and Chemical Technology SB RAS, Federal Research Center “Krasnoyarsk Scientific Center of the SB RAS” Krasnoyarsk, Russian Federation; Bryazgin, Alexandr A.: Budker Institute of Nuclear Physics SB RAS Novosibirsk, Russian Federation
- Keywords
- radiation-thermal synthesis; chitosan; acrylamide; copolymers; betulin; mechanocomposites; dissolution rate
- Abstract
Graft copolymers of chitosan with acrylamide were obtained by the radiation-thermal method using accelerated electrons. The formation of graft copolymers was confirmed by IR spectroscopy and gel permeation chromatography. It is shown that the efficiency and degree of grafting depend on the dose of ionizing radiation, and pass through a maximum with increasing dose. The conditions for obtaining copolymers with a high yield of the product were found. The resulting copolymers were used to obtain betulin composites using mechanochemical processing. It has been shown that the rate of release of betulin into an aqueous solution during the dissolution of the composite depends on the pH of the solution, which makes it possible to consider mechanocomposites based on copolymers of chitosan with acrylamide as promising means for controlled drug delivery
- Pages
- 420–430
- DOI
- 10.17516/1998-2836-0305
- Paper at repository of SibFU
- https://elib.sfu-kras.ru/handle/2311/148513
Journal of Siberian Federal University. Chemistry / Radiation-Thermal Synthesis of Copolymers of Chitosan with Acrylamide as a Means of Betulin Delivering
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