Journal of Siberian Federal University. Biology / A New Method for Treating Burn Wounds Using Targeted Delivery of Medicinal Substances by Magnetic Nanocarrier (Experimental Part)

Full text (.pdf)
Issue
Journal of Siberian Federal University. Biology. 2022 15 (3)
Authors
Bogatikov, Alexander A.; Dobretsov, Konstantin G.; Melikhova, Marina V.; Rozhko, Mikhail A.; Lapina, Natalia V.; Stolyar, Sergey V.; Yaroslavtsev, Roman N.; Bayukov, Oleg A.; Tyumentseva, Anna V.; Nikolaeva, Elena D.; Tyutrina, Ekaterina S.; Zinovev, Evgenii V.
Contact information
Bogatikov, Alexander A.: L.G. Sokolov North-West Regional Scientific and Clinical Center of the Federal Medical-Biological Agency St. Petersburg, Russian Federation; Dobretsov, Konstantin G.: Russian State Social University Moscow, Russian Federation; Melikhova, Marina V.: Institute of Toxicology of the Federal Medical-Biological Agency St. Petersburg, Russian Federation; Rozhko, Mikhail A.: Institute of Toxicology of the Federal Medical-Biological Agency St. Petersburg, Russian Federation; Lapina, Natalia V.: Institute of Toxicology of the Federal Medical-Biological Agency St. Petersburg, Russian Federation; Stolyar, Sergey V.: Federal Research Center “Krasnoyarsk Scientific Center SB RAS” Krasnoyarsk, Russian Federation; ORCID: 0000-0003-4310-091X; Yaroslavtsev, Roman N.: Federal Research Center “Krasnoyarsk Scientific Center SB RAS” Krasnoyarsk, Russian Federation; ORCID: 0000-0002-6791-7492; Bayukov, Oleg A.: Federal Research Center “Krasnoyarsk Scientific Center SB RAS” Krasnoyarsk, Russian Federation; Tyumentseva, Anna V.: Federal Research Center “Krasnoyarsk Scientific Center SB RAS” Krasnoyarsk, Russian Federation; ORCID: 0000-0002-2269-0298; Nikolaeva, Elena D.: Federal Research Center “Krasnoyarsk Scientific Center SB RAS” Krasnoyarsk, Russian Federation; ; ORCID: 0000-0002-5298-828X; Tyutrina, Ekaterina S.: Federal Research Center “Krasnoyarsk Scientific Center SB RAS” Krasnoyarsk, Russian Federation; Prof. Voino-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk, Russian Federation; Zinovev, Evgenii V.: I. I. Dzhanelidze Saint-Petersburg Research Institute of Emergency Medicine St. Petersburg, Russian Federation; ORCID: 0000-0002-2493-5498
Keywords
nanoparticles; ferrihydrite; levomekol; magnetic field; wound; burn; wound infection; regeneration; topical therapy
Abstract

Experimental studies have been carried out on laboratory animals to investigate the effectiveness of targeted delivery of levomekol ointment using magnetic nanoparticles and an external magnetic field for treatment of thermal burns. The study involved 20 rats, with two burns on each. The rats were divided into 4 groups: untreated; treated with levomekol ointment; treated with levomekol ointment associated with nanoparticles and an external magnetic field; and treated with magnetic field alone. Histological examination was conducted on Day 14, and in all groups, in the thermal burn zone of the skin there were signs of deep three- and four-degree burns with necrosis spread through the dermis, reaching the muscle. In the group with levomekol ointment associated with nanoparticles and magnetic field, inflammation was decreased, and focal granulation tissue formation was observed. Thus, histological studies of the burn wound process in laboratory animals showed that the use of an innovative biologically active wound healing agent based on nanoparticles in combination with the levomecol ointment improved tissue regeneration and accelerated epithelialization, which enhanced the effectiveness of burn wound treatment. The use of an external magnetic field facilitated targeted delivery of the therapeutic nanosystem and maintenance of the optimal concentration of the drug in the wound

Pages
422–436
DOI
10.17516/1997-1389-0396
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/149186

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