Siberian Federal University

This article describes the gramm-scale synthesis of novel 2-(3-methyl‑4-nitroso‑5-phenyl‑1H‑pyrazol‑1-yl)benzo[d]thiazole by cyclocondensation of hydrazinylbenzothiazole with 2-hydroxyimino‑1,3-butanedione. We show the possibility of transformation of 1-(benzothiazol‑2-yl)-4-nitrosopyrazole to new nitro-, amino-, imino-, amido- and arylazo derivatives. The obtained for the first time compounds were characterized by using IR, 1H NMR, 13C NMR, COSY, HSQC, HMBC, UV–Vis spectroscopy and chromatograhy-mass spectrometry. The study of the antioxidant activity of new benzothiazolylpyrazoles showed that azomethine derivatives have very good activity, which is compared to hesperidin and ferulic acid