Siberian Federal University

Issue

Journal of Siberian Federal University. Biology. 2023 16 (2)

Authors

Kurashov, Evgeny A.; Fedorova, Elena V.; Krylova, Julia V.; Kapustina, Larisa L.; Mitrukova, Galina G.; Protopopova, Elena V.

Contact information

Kurashov, Evgeny A.: Institute of Lake Science of the RAS, a separate subdivision of the St. Petersburg Federal Research Center of the RAS Saint Petersburg, Russian Federation; Papanin Institute for Biology of Inland Waters, RAS Borok, Russian Federation; ; ORCID: 0000-0002-4486-2804; Fedorova, Elena V.: Quantori, Global Headquarters Cambridge, USA; ORCID: 0000-0003-1667-5240; Krylova, Julia V.: Institute of Lake Science of the RAS, a separate subdivision of the St. Petersburg Federal Research Center of the RAS Saint Petersburg, Russian Federation; Papanin Institute for Biology of Inland Waters, RAS Borok, Russian Federation; ORCID: 0000-0002-4274-2358; Kapustina, Larisa L.: Institute of Lake Science of the RAS, a separate subdivision of the St. Petersburg Federal Research Center of the RAS Saint Petersburg, Russian Federation; ORCID: 0000-0002-7135-3300; Mitrukova, Galina G.: Institute of Lake Science of the RAS, a separate subdivision of the St. Petersburg Federal Research Center of the RAS Saint Petersburg, Russian Federation; Saint-Petersburg State Chemical and Pharmaceutical University Saint Petersburg, Russian Federation; ORCID: 0000-0002-4128-7840; Protopopova, Elena V.: Institute of Lake Science of the RAS, a separate subdivision of the St. Petersburg Federal Research Center of the RAS Saint Petersburg, Russian Federation; ORCID: 0000-0001-5376-7019

Keywords

SAR; PASS; allelopathy; allelochemicals; macrophytes; cyanobacteria; fatty acids; algaecides; SAR; PASS

Abstract

Controlling harmful cyanobacterial “blooms” through developing a new generation of algaecides based on allelochemical substances is a challenge facing modern aquatic ecology and biotechnology. The present article is devoted to the use of the SAR (Structure-Activity-Relationship) information technology to identify allelochemicals from aquatic macrophytes (floating-leaved Nuphar lutea (L.) Sm. and several species of submerged macrophytes: Ceratophyllum demersum L., Myriophyllum spicatum L., Elodea canadensis Michx, and species of the genus Potamogeton) effective against planktonic cyanobacteria. Detection and identification of compounds were performed using gas chromatography-mass spectrometry. The PASS (Prediction of Activity Spectra for Substances) computer program has been applied to predict biological activity spectra of the major components of macrophyte metabolomes and discover their ecological potential against cyanobacteria. A study of the biological activities of major low-molecular-weight organic compounds showed that monocarboxylic acids, gallic acid, cis‑6-octadecenoic acid, cis‑9-octadecenoic acid, palmitoleic acid, linolenic acid, and 9-cis‑12-cis-linoleic acid are the most promising compounds for the experimental verification and creation of nature-like algaecides of a new generation. PASS predictions were successfully compared to the available information on the biological activity of those compounds and confirmed experimentally. The present study shows that some organic acids significantly inhibit the growth of Synechocystis aquatilis Sauvageau and Aphanizomenon flos-aquae Ralfs ex Bornet and Flahault and can be used as algaecides for suppression of cyanobacteria. The inhibitory effect of the combined mixture of these allelochemicals is stronger than the effect of each individual component, suggesting that there are various mechanisms of cyanobacterial growth inhibition

Pages

232–251

EDN

SELYZZ

Paper at repository of SibFU

https://elib.sfu-kras.ru/handle/2311/150841

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).