Journal of Siberian Federal University. Biology / Approaches to Correction of Adaptive Responses of Experimental Animals during the Autumnal Equinox

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Issue
Journal of Siberian Federal University. Biology. 2024 17 (2)
Authors
Doroshenko, Olga S.; Zamoshchina, Tatiana A.; Gostyukhina, Alyona A.; Prokopova, Alyona V.; Svetlik, Michael V.; Zaitsev, Konstantin V.; Zhukova, Oksana B.
Contact information
Doroshenko, Olga S. : Federal Scientific and Clinical Center for Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency Moscow, Russian Federation; National Research Tomsk State University Tomsk, Russian Federation; ; ORCID: 0000-0003-4764-4842; Zamoshchina, Tatiana A. : Federal Scientific and Clinical Center for Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency Moscow, Russian Federation; Siberian State Medical University of the Ministry of Health of the Russian Federation; National Research Tomsk State University Tomsk, Russian Federation; ORCID: 0000-0003-1868-9793; Gostyukhina, Alyona A. : Federal Scientific and Clinical Center for Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency Moscow, Russian Federation; National Research Tomsk State University Tomsk, Russian Federation; ORCID: 0000-0003-3655-6505; Prokopova, Alyona V. : Federal Scientific and Clinical Center for Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency Moscow, Russian Federation; National Research Tomsk State University Tomsk, Russian Federation; ORCID: 0000-0001-7292-1253; Svetlik, Michael V. : Siberian State Medical University of the Ministry of Health of the Russian Federation; National Research Tomsk State University Tomsk, Russian Federation; ORCID: 0000-0003-3030-2580; Zaitsev, Konstantin V. : Federal Scientific and Clinical Center for Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency Moscow, Russian Federation; ORCID: 0000-0003-6504-5232; Zhukova, Oksana B. : Federal Scientific and Clinical Center for Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency Moscow, Russian Federation; ORCID: 0000-0001-5016-7288
Keywords
stress; adaptation; antler baths; ethylmethylhydroxypyridine succinate; autumnal equinox
Abstract

The present study reports the results of analyzing the adaptive responses of laboratory rats (n=120, Wistar males) with physical fatigue (after the swimming test) and light desynchronosis during the autumnal equinox and the possibility of their pharmacological or physiotherapeutic correction. Rehabilitation procedures were carried out using water and antler baths for 10 days immediately after exposure to stress factors. The reference agent was ethylmethylhydroxypyridine succinate, which was injected at a dose of 10 mg/kg of animal weight 30 minutes before the swimming test. Rehabilitation physiotherapeutic measures in the form of antler baths proved to be more effective both at the hormonal and behavioral levels only in the case of desynchronosis associated with the extension of the light phase of the day. In contrast to rehabilitation procedures, preventive measures using ethylmethylhydroxypyridine succinate were effective regardless of the type of deprivation and only at the behavioral level, resulting in stabilization of the behavioral state

Pages
225–234
EDN
QCFQSV
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/153203

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