Journal of Siberian Federal University. Mathematics & Physics / Electrochemical Aptasensor for Detection of Lung Cancer Tumor Markers in Blood Plasma

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Issue
Journal of Siberian Federal University. Mathematics & Physics. 2024 17 (6)
Authors
Glazyrin, Yuri E.; Zamay, Galina S.; Kichkailo, Anna S.; Zamay, Tatiana N.; Pats, Yuri S.; Zamay, Sergei S.; Lukyanenko, Kirill A.; Kolovskaya, Olga S.
Contact information
Glazyrin, Yuri E.: FRC Krasnoyarsk Science Center of the SB RAS Krasnoyarsk, Russian Federation; Prof. V. F.Voino-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk, Russian Federation; OCRID: 0000-0002-2826-5751; Zamay, Galina S.: FRC Krasnoyarsk Science Center of the SB RAS Krasnoyarsk, Russian Federation; Prof. V. F.Voino-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk, Russian Federation; ; Kichkailo, Anna S.: FRC Krasnoyarsk Science Center of the SB RAS Krasnoyarsk, Russian Federation; Prof. V. F.Voino-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk, Russian Federation; ; Zamay, Tatiana N.: FRC Krasnoyarsk Science Center of the SB RAS Krasnoyarsk, Russian Federation; Prof. V. F.Voino-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk, Russian Federation; OCRID: 0000-0002-7493-8742; Pats, Yuri S.: Prof. V. F.Voino-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk, Russian Federation; ; Zamay, Sergei S.: FRC Krasnoyarsk Science Center of the SB RAS Krasnoyarsk, Russian Federation; Lukyanenko, Kirill A.: FRC Krasnoyarsk Science Center of the SB RAS Krasnoyarsk, Russian Federation; Prof. V. F.Voino-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk, Russian Federation; OCRID: 0000-0002-1115-6735; Kolovskaya, Olga S.: FRC Krasnoyarsk Science Center of the SB RAS Krasnoyarsk, Russian Federation; Prof. V. F.Voino-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk, Russian Federation
Keywords
aptamers; lung cancer; electrochemical aptasensor; blood plasma tumor biomarkers
Abstract

The study investigates the possibility of diagnosing lung cancer through the simultaneous detection of six tumor biomarkers of this disease (CYFRA21-1, EpCAM, PLAUR, LIFR, ProGRP, and CEA) in blood plasma. The levels of these proteins in blood plasma were determined using square-wave voltammetry with multiplexed electrochemical chips modified with DNA aptamers. The results obtained in the study demonstrated the capability of the multiplex electrochemical aptasensor to simultaneously detect in blood plasma such traditionally used lung cancer tumor markers as CYFRA21-1, EpCAM, PLAUR, LIFR, ProGRP, and CEA

Pages
761–768
EDN
MKGESG
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/154109