Siberian Federal University

Carbonate hydroxyapatite composites were synthesized from model media with different contents of high-molecular hyaluronic acid. The dynamics of their dissolution in acetate buffer solution and 0,9 % sodium chloride solution was studied. It was shown that all powders are more soluble in weakly acidic conditions. Their resorption rate depends on the degree of apatite crystallinity and the polysaccharide content in the initial solution. The results of powder cytotoxicity tests on the FetMSC cell line using the MMT test are presented. It was found that the composites have an insignificant cytotoxic effect on cultured cells. Cell viability improves with a longer period of sample incubation. Composites dissolving at an average rate in physiological solutions exhibit a consistently positive effect on cells. The obtained composites are promising as non-toxic materials for accelerating implant bioresorption involving osteoclasts in vivo