Journal of Siberian Federal University. Chemistry / Improved Method of Preparation of Betulonic Acid from Birch Bark and its Antitumor Activity

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Supplementary material
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Issue
Journal of Siberian Federal University. Chemistry. 2025 18 (2)
Authors
Skurydina, Evgenia S.; Kuznetsova, Svetlana A.; Levdansky, Vladimir A.; Morgulis, Irina I.; Garyntseva, Natalya V.; Kuznetsov, Boris N.
Contact information
Skurydina, Evgenia S.: Institute of Chemistry and Chemical Technology SB RAS, Federal Research Center “Krasnoyarsk Scientific Center of the SB RAS” Krasnoyarsk, Russian Federation; ; Kuznetsova, Svetlana A. : Institute of Chemistry and Chemical Technology SB RAS, Federal Research Center “Krasnoyarsk Scientific Center of the SB RAS” Krasnoyarsk, Russian Federation; Levdansky, Vladimir A. : Institute of Chemistry and Chemical Technology SB RAS, Federal Research Center “Krasnoyarsk Scientific Center of the SB RAS” Krasnoyarsk, Russian Federation; Morgulis, Irina I. : International Scientific Center for Research on Extreme Organismal States International Scientific Center for Research on Extreme States of the Organism FRC KSC SB RAS Krasnoyarsk, Russian Federation; Garyntseva, Natalya V. : Institute of Chemistry and Chemical Technology SB RAS, Federal Research Center “Krasnoyarsk Scientific Center of the SB RAS” Krasnoyarsk, Russian Federation; Krasnoyarsk State Agrarian University Krasnoyarsk, Russian Federation; Kuznetsov, Boris N.: Institute of Chemistry and Chemical Technology SB RAS, Federal Research Center “Krasnoyarsk Scientific Center of the SB RAS” Krasnoyarsk, Russian Federation
Keywords
birch bark; betulin; betulonic acid; antitumor activity; Ehrlich ascites carcinoma
Abstract

The paper describes an improved single-stage method for obtaining betulonic acid from birch bark with recrystallization from ethanol. The structure and composition of the obtained betulonic acid were confirmed by FTIR, NMR spectroscopy and elemental analysis. Thermal studies of betulonic acid were carried out using differential scanning calorimeter (DSC). The antitumor activity of betulonic acid and betulin was studied on Ehrlich ascites carcinoma culture in vivo experiments. It was found that under the influence of betulin and betulonic acid the content of dead cells of Ehrlich ascites carcinoma increased. It was shown that betulonic acid has a protective effect on the hematopoiesis system and does not have a toxic effect on the body

Pages
217–228
EDN
AHJXYW
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/156205