Journal of Siberian Federal University. Biology / Biochemical Aspects of Mercury Neurotoxicity in an Experimental Study

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Issue
Journal of Siberian Federal University. Biology. 2025 18 (2)
Authors
Shchepetkova, Kristina M.; Batotsyrenova, Ekaterina G.; Kashuro, Vadim A.; Khalchitskiy, Sergey E.
Contact information
Batotsyrenova, Ekaterina G. : Saint Petersburg State Pediatric Medical University of the Ministry of Health of the Russian Federation Saint Petersburg, Russian Federation; Golikov Research Clinical Center of Toxicology of the Federal Medical-Biological Agency Saint Petersburg, Russian Federation; ORCID: 0000-0003-3827-4579; Kashuro, Vadim A.: Saint Petersburg State Pediatric Medical University of the Ministry of Health of the Russian Federation Saint Petersburg, Russian Federation; The Herzen State Pedagogical University of Russia Saint Petersburg, Russian Federation; Saint Petersburg State University Saint Petersburg, Russian Federation; ORCID: 0000-0002-7892-0048; Khalchitskiy, Sergey E. : H. Turner National Medical Research Center for Children’s Orthopedics and Trauma Surgery of the Ministry of Health of the Russian Federation Saint Petersburg, Russian Federation; ORCID: 0000-0003-1467-8739
Keywords
brain; antioxidant system; lipid peroxidation; mercury acetate; chronic poisoning
Abstract

Mercury belongs to the substances of hazard class I, and even in small amounts, it can disrupt the functions of various organs and tissues. Data reported in numerous studies indicate the pro-oxidant effect of mercury. Brain tissue is particularly sensitive to the disturbance in the redox balance. The antioxidant protection system of the cell plays an important role in maintaining the parameters of the internal environment constant. Changes in the parameters of the antioxidant system and lipid peroxidation after low- dose chronic poisoning with inorganic forms of mercury have not been studied sufficiently. Therefore, the aim of the present work was to study changes in the parameters of the antioxidant system and lipid peroxidation in rat brain tissues after chronic low-dose poisoning with mercury acetate. After 30 days of administration of mercury acetate at a dose of 4 mg/kg, mercury content and parameters of the antioxidant system and lipid peroxidation were determined in rat brain homogenate. Chronic administration of mercury acetate led to the accumulation of mercury in the brains of animals in the treatment group. The mercury content in the treatment group increased by 402.5 times compared with the control group. In the group of rats exposed to mercury acetate, the activity of superoxide dismutase increased by 23.4 %, glutathione peroxidase by 13.6 %, and glucose-6-phosphate dehydrogenase by 13.9 % compared with the control group. The content of reduced glutathione was 33.4 % lower compared with the control parameters. A 30-day administration of mercury acetate led to a 20 % increase in the content of malonic dialdehyde in the brain tissues of rats in the treatment group compared with the control group. The results demonstrated the disruption of the homeostasis of the antioxidant system, which suggested the development of oxidative stress

Pages
206–215
EDN
FTZRHQ
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/156630

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