Journal of Siberian Federal University. Mathematics & Physics / Aptamer-functionalized Magnetic Nanoparticles as a Contrast Agent for Magnetic Resonance Imaging

Full text (.pdf)
Issue
Journal of Siberian Federal University. Mathematics & Physics. Prepublication
Authors
Stolyar, Sergey V.; Kichkailo, Anna S.; Yaroslavtsev, Roman N.; Bayukov, Oleg A.; Nikolaeva, Elena D.; Rautskii, Mikhail V.; Kryukova, Olga V.; Pakhomova, Vera G.; Koshmanova, Anastasia A.; Morozov, Eugene V.
Contact information
Stolyar, Sergey V. : Federal Research Center Krasnoyarsk Scientific Center SB RAS Kirensky Institute of Physics FRC KSC SB RAS Krasnoyarsk, Russian Federation; OCRID: 0000-0003-4310-091X; Kichkailo, Anna S. : Federal Research Center Krasnoyarsk Scientific Center SB RAS Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk, Russian Federation; OCRID: 0000-0003-1054-4629; Yaroslavtsev, Roman N. : Federal Research Center Krasnoyarsk Scientific Center SB RAS Kirensky Institute of Physics FRC KSC SB RAS Krasnoyarsk, Russian Federation; OCRID: 0000-0002-6791-7492; Bayukov, Oleg A. : Kirensky Institute of Physics FRC KSC SB RAS Krasnoyarsk, Russian Federation; Nikolaeva, Elena D. : Federal Research Center Krasnoyarsk Scientific Center SB RAS Krasnoyarsk, Russian Federation; OCRID: 0000-0002-5298-828X; Rautskii, Mikhail V. : Kirensky Institute of Physics FRC KSC SB RAS Krasnoyarsk, Russian Federation; Kryukova, Olga V. : Federal Research Center Krasnoyarsk Scientific Center SB RAS Krasnoyarsk, Russian Federation; Pakhomova, Vera G. : Federal Research Center Krasnoyarsk Scientific Center SB RAS Krasnoyarsk, Russian Federation; Koshmanova, Anastasia A. : Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk, Russian Federation; Morozov, Eugene V. : Kirensky Institute of Physics FRC KSC SB RAS Institute of Chemistry and Chemical Technology FRC KSC SB RAS Krasnoyarsk, Russian Federation
Keywords
nanoparticles; magnetite; arabinogalactan; aptamers; MRI
Abstract

The possibility of using superparamagnetic nanoparticles based on magnetite with a polysac- charide coating functionalized with an aptamer for in vivo tumor imaging using MRI was studied using Ehrlich ascites carcinoma as an example. The synthesized nanoparticles were studied using transmission electron microscopy, M¨ossbauer spectroscopy and ferromagnetic resonance. The synthesized nanoparti- cles were conjugated with the As42 aptamer specific to Ehrlich carcinoma cells (As42-Fe3O4-AG). The possibility of using As42-Fe3O4-AG as a contrast agent for MRI imaging of tumors in mice that formed in the lungs of animals 2 weeks after intrapulmonary administration of Ehrlich ascites carcinoma cells was shown. Aptamer AS42 specifically delivers superparamagnetic magnetite-based nanoparticles (Fe3O4- AG) that provide contrast in MRI tissue scans. The nanoparticles allow for specific recognition of solid lung tumors using MRI, which is confirmed by autopsy

Pages
819–827
EDN
PKRKZK
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/157506