Journal of Siberian Federal University. Biology: Distribution and Resorption of Intravenously Administrated Polymer Microparticles in Tissues of Internal Organs of Laboratory Animals

Journal of Siberian Federal University. Biology / Distribution and Resorption of Intravenously Administrated Polymer Microparticles in Tissues of Internal Organs of Laboratory Animals

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Issue: Journal of Siberian Federal University. Biology. 2009 2 (4)
Authors: Shishatskaya, Ekaterina I.; Goreva, Anastasya V.; Kalacheva, Galina S.; Volova, Tatiana G.
Contact information: Shishatskaya, Ekaterina I. : Institute of Biophysics SB RAS Siberian Federal University; Akademgorodok, Krasnoyarsk, 660036 Russia 79 Svobodny, Krasnoyarsk, 660041 Russia, e-mail: ; Goreva, Anastasya V. : Institute of Biophysics SB RAS; Akademgorodok, Krasnoyarsk, 660036 Russia,; Kalacheva, Galina S. : Institute of Biophysics SB RAS; Akademgorodok, Krasnoyarsk, 660036 Russia,; Volova, Tatiana G. : Institute of Biophysics SB RAS Siberian Federal University; Akademgorodok, Krasnoyarsk, 660036 Russia 79 Svobodny, Krasnoyarsk, 660041 Russia,
Keywords: resorbable polyhydroxybutyrate; microparticles; intravenous administration; 14C; tissues of internal organs
Abstract: Resorbable polymer of hydroxybutyric acid labeled with ¹⁴C was used to prepare microparticles (diameter smaller than 3.8 μm ) that were then injected to laboratory animals (Wistar rats) via the tail vein, without causing any adverse effects on growth and development of the animals or altering the macroscopic and microscopic structure of the tissues of internal organs. Examination of the distribution of microparticles among the internal organs and the dynamics of accumulation of carbon-containing polymer degradation products in internal organs showed that the main targets for microparticles were tissues of the liver, kidneys, and spleen. The most rapid degradation of the polymer of microparticles occurred in the spleen and liver. The presence of high molecular weight polymer registered in internal organs suggested that the microparticles remained undecomposed and that the PHB microparticles could function in vivo for extended periods of time (up to 12 weeks).
Pages: 453-465
Paper at repository of SibFU: https://elib.sfu-kras.ru/handle/2311/1624

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