Journal of Siberian Federal University. Chemistry / The Protonation and Synthesis of Protonated Ciprofloxacin Compounds with d-Elements Bromides

Full text (.pdf)
Issue
Journal of Siberian Federal University. Chemistry. 2010 3 (1)
Authors
Golovnev, Nicolay N.; Petrov, Alexander I.; Dorochova, Nadezhda V.; Kirik, Sergey D.; Golovneva, Irina I.
Contact information
Golovnev, Nicolay N. : Siberian Federal University , Russia 660041, Krasnoyarsk, Svobodny, 79 email: ; Petrov, Alexander I. : Siberian Federal University , Russia 660041, Krasnoyarsk, Svobodny, 79; Dorochova, Nadezhda V. : Siberian Federal University , Russia 660041, Krasnoyarsk, Svobodny, 79; Kirik, Sergey D. : Siberian Federal University , Russia 660041, Krasnoyarsk, Svobodny, 79; Golovneva, Irina I. : Siberian Federal University , Russia 660041, Krasnoyarsk, Svobodny, 79
Keywords
ciprofloxacin; protonation; sulphuric acid; d-elements
Abstract

The third stepwise protonation constant (K3) of ciprofloxacin anion (C17H17FN3O3, Cf) has been determined by spectrophotometry. The third proton addition to Cf in sulphuric acid aqueous solutions takes place beyond [H+] = 4M only, leading to CfH3+ formation. pK3 values obtained by Hammett and Cox-Yates methods make up 4.75±0.05 and 4.74±0.06 respectively. The new compounds CfH3[ZnBr]4, CfH3[CdBr4]. CfH3[HgBr4] and CfH3[CoBr4] have been synthesized, their crystallographic parameters and thermal properties have been studied.

Pages
58-63
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/1748