Siberian Federal University 
- Issue
- Journal of Siberian Federal University. Biology. 2016 9 (1)
- Authors
- Shishatskaya, Ekaterina I.
- Contact information
- Shishatskaya, Ekaterina I.:Institute of Biophysics of SB RAS 50/50 Akademgorodok, Krasnoyarsk, 660036, Russia; E-mail:
- Keywords
- biopolymers; polyhydroxyalkanoates; PHAs; implants; degradation in vivo
- Abstract
The present review summarizes the literature data on the degradation dynamics of polyhydroxyalkanoates (PHAs) in vivo and the authors’ results obtained over a more than ten years of research, which included implantation of experimental polymer items shaped as microparticles, films, filaments, and 3D constructs subcutaneously, intramuscularly, and into internal organs of animals for long periods of time. The study shows that PHA degradation is determined by the chemical structure of the polymer, the shape of the implant, and implantation site; PHA degradation is slow, occurring via humoral and cellular pathways, usually beginning on the surface of the implants, with no local defects developing or strength decreasing dramatically. PHA biodegradation involves macrophages and foreign body giant cells. PHA products are resistant to the effects of biological media and are capable of functioning in vivo for between several months and one year or longer
- Pages
- 21-32
- Paper at repository of SibFU
- https://elib.sfu-kras.ru/handle/2311/20178
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).