Journal of Siberian Federal University. Chemistry: The Synthesis of Agent Produced by Interaction of the Complex Trans-Dichlorodiamminplatinum(II) with Arabinogalactan and its Properties

Journal of Siberian Federal University. Chemistry / The Synthesis of Agent Produced by Interaction of the Complex Trans-Dichlorodiamminplatinum(II) with Arabinogalactan and its Properties

Issue: Journal of Siberian Federal University. Chemistry. 2016 9 (1)
Authors: Starkov, Alexander K.; Kozuchovskaya, Galina A.; Pavlenko, Nina I.
Contact information: Starkov, Alexander K.:Institute of Chemistry and Chemical Technology SB RAS 50/24 Akademgorodok, Krasnoyarsk, 660036, Russia; Kozuchovskaya, Galina A.:Institute of Chemistry and Chemical Technology SB RAS 50/24 Akademgorodok, Krasnoyarsk, 660036, Russia; Pavlenko, Nina I.:Institute of Chemistry and Chemical Technology SB RAS 50/24 Akademgorodok, Krasnoyarsk, 660036, Russia; E-mail:
Keywords: complex compounds of platinum; synthesis; physicochemical properties; arabinoga-lactan; anticancer activity
Abstract: The obtained new product of reaction of the complex trans-dichlorodiaminplatinum(II) with arabinogalactan was characterized by XRD, IR-spectroscopy, UF-spetrophotometry and thermogravimetry. The composition and structure of this product was studied. It has been shown that trans-dichlorodiaminplatinum(II) associated with arabinogalactan through –C-O-C- amino hydrogen of the original complex. The synthesized product has the improved pharmacological properties being more soluble, less toxic and shows a greater anticancer activity as compared to cis-dichlorodiaminplatinum(II)
Pages: 42-48
Paper at repository of SibFU: https://elib.sfu-kras.ru/handle/2311/20294