Journal of Siberian Federal University. Biology / Cord Blood Vitamin D, Total IgE, Cytokines Concentrations and Polyunsaturated Fatty Acids Spectrum in Newborns from Mothers with Atopic Dermatitis History

Full text (.pdf)
Issue
Journal of Siberian Federal University. Biology: 2010, Vol. 3, Issue 4
Authors
Tereshchenko, Sergey Yu.; Prahin, Efim I.; Novitzkiy, Ivan A.; Tzhai, Vitaly B.; Gladyshev, Michail I.; Sushchik, Nadezhda N.; Kalachova, Galina S.; Shakina, Natalya A.; Isakov, Igor V.; Gorbacheva, Natalya N.
Contact information
Tereshchenko, Sergey Yu. : Medical Research Institute for Northern Problems , 3g Partizana Geleznyaka, Krasnoyarsk, 660022 Russia , e-mail: ; Prahin, Efim I. : Medical Research Institute for Northern Problems Krasnoyarsk State Medical University , 3g Partizana Geleznyaka, Krasnoyarsk, 660022 Russia 1 Partizana Geleznyaka, Krasnoyarsk 660022, Russia; Novitzkiy, Ivan A. : Medical Research Institute for Northern Problems Krasnoyarsk State Medical University , 3g Partizana Geleznyaka, Krasnoyarsk, 660022 Russia 1 Partizana Geleznyaka, Krasnoyarsk 660022, Russia; Tzhai, Vitaly B. : Krasnoyarsk State Medical University , 1 Partizana Geleznyaka, Krasnoyarsk 660022, Russia; Gladyshev, Michail I. : Institute of Biophysics of Siberian Branch of Russian Academy of Sciences Siberian Federal University , 50 Akademgorodok, Krasnoyarsk, 660036 Russia 79 Svobodny pr., Krasnoyarsk, 660041 Russia; Sushchik, Nadezhda N. : Institute of Biophysics of Siberian Branch of Russian Academy of Sciences Siberian Federal University , 50 Akademgorodok, Krasnoyarsk, 660036 Russia 79 Svobodny pr., Krasnoyarsk, 660041 Russia; Kalachova, Galina S. : Institute of Biophysics of Siberian Branch of Russian Academy of Sciences , 50 Akademgorodok, Krasnoyarsk, 660036 Russia; Shakina, Natalya A. : Krasnoyarsk Regional Centre of Prevention and Contest against HIV and other Infections , 45 Marks str., Krasnoyarsk, 660049 Russia; Isakov, Igor V. : Krasnoyarsk Regional Centre of Prevention and Contest against HIV and other Infections , 45 Marks str., Krasnoyarsk, 660049 Russia; Gorbacheva, Natalya N. : Medical Research Institute for Northern Problems , 3g Partizana Geleznyaka, Krasnoyarsk, 660022 Russia
Keywords
newborn; cord blood; cytokines; vitamin D; fatty acids; erythrocyte membranes; atopic dermatitis
Abstract

At the present time there is a hypothesis on the presence of congenital polyunsaturated fatty acids (PUA) and vitamin D metabolism disturbance, which plays its role in the pathogenesis of atopic dermatitis (AD). On the other hand, the maternal atopy may be considered as one of the important predictor for allergic diseases in children. However, does this factor influence on Th1/Th2 balance forming, cord blood vitamin D and PUA concentrations already on the moment of infants birth? We used flow cytometry and ELISE techniques to study IFN , IL-1 , IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, TNF , TNF , IL-13, IL-18, IP-10, total IgE, vitamin D cord blood concentrations and mass spectrometry method to study the content of PUA in cord blood erythrocytes. These markers were studied in two newborns groups: the 1-st one is newborns from mothers without AD history (n=29) and 2-nd one is newborns from mothers with AD history (n=19). Statistical analysis was performed using the Mann-Whitney U-test. In neonates from mothers with presence AD history we found decreasing of IL-13, IL-18 cord blood concentrations and gamma-linolenic (GLA) acid percentage in cord blood erythrocytes. Thus, maternal history of AD may influence on IL-13, IL-18 and GLA production already on the moment of infant's birth which suggests genetic background and may be used as the early markers of AD predisposition.

Pages
407-417
Paper at repository of SibFU
http://elib.sfu-kras.ru/handle/2311/2252

Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).