Journal of Siberian Federal University. Chemistry: Spectrophotometric Determination of Mediborol in its Oil Solutions

Journal of Siberian Federal University. Chemistry / Spectrophotometric Determination of Mediborol in its Oil Solutions

Issue: Journal of Siberian Federal University. Chemistry. 2011 4 (2)
Authors: Shelekhova, Vera A.; Plotnikov, Mark B.; Krasnov, Efim A.
Contact information: Shelekhova, Vera A. : Sibirian State Medical University , 2 Moscowski Trakt st., Tomsk, 634050 Russia; Plotnikov, Mark B. : Institute of Pharmacology, Tomsk Scientific Center, Siberian Branch, Russian Academy of Medical Sciences , 3 Lenin Avenue, Tomsk, 634028 Russia; Krasnov, Efim A. : Sibirian State Medical University , 2 Moscowski Trakt st., Tomsk, 634050 Russia , e-mail:
Keywords: mediborol; oil solution; the Firordt's method; spectrophotometry; validation
Abstract: The present study suggests the UV-spectrophotometric assay of mediborol in its oil solutions, which is based on the Firordts method and does not require previous separation of the active substance from the oil components. The validation data of the developing method showed that the dependence of real content from observed content of mediborol in the concentration range1,6 - 2,4 % is linear with correlation coefficients of R² = 0,999 for the solution in peach oil and R² = 0,995 - in the olive. Accuracy is in the range of 98,72 to 100,83 % and from 98,64 to 101,11 % for mediborols solutions in peach and olive oils, respectively. The relative error in determination of mediborol ranges from 2,09 to 2,81 %.
Pages: 183-190
Paper at repository of SibFU: https://elib.sfu-kras.ru/handle/2311/2467