Journal of Siberian Federal University. Chemistry / Solubility Study of Betulonic Acid in the Presence of Hydroxypropyl-γ-cyclodextrin by Capillary Electrophoresis

Full text (.pdf)
Issue
Journal of Siberian Federal University. Chemistry. 2016 9 (2)
Authors
Popova, Olesya V.; Sursyakova, Viktoria V.; Burmakina, Galina V.; Maksimov, Nikolay G.; Levdansky, Vladimir A.; Rubaylo, Anatoly I.
Contact information
Popova, Olesya V.: Institute of Chemistry and Chemical Technology SB RAS FRC “Krasnoyarsk Science Center SB RAS” 50/24 Akademgorodok, Krasnoyarsk, 660036, Russia; E-mail : ; Sursyakova, Viktoria V.: Institute of Chemistry and Chemical Technology SB RAS FRC “Krasnoyarsk Science Center SB RAS” 50/24 Akademgorodok, Krasnoyarsk, 660036, Russia; E-mail: ; Burmakina, Galina V.: Institute of Chemistry and Chemical Technology SB RAS FRC “Krasnoyarsk Science Center SB RAS” 50/24 Akademgorodok, Krasnoyarsk, 660036, Russia; Siberian Federal University 79 Svobodny, Krasnoyarsk, 660041, Russia; Maksimov, Nikolay G.: Institute of Chemistry and Chemical Technology SB RAS FRC “Krasnoyarsk Science Center SB RAS” 50/24 Akademgorodok, Krasnoyarsk, 660036, Russia; Levdansky, Vladimir A.: Institute of Chemistry and Chemical Technology SB RAS FRC “Krasnoyarsk Science Center SB RAS” 50/24 Akademgorodok, Krasnoyarsk, 660036, Russia; Rubaylo, Anatoly I.: Institute of Chemistry and Chemical Technology SB RAS FRC “Krasnoyarsk Science Center SB RAS” 50/24 Akademgorodok, Krasnoyarsk, 660036, Russia; Siberian Federal University 79 Svobodny, Krasnoyarsk, 660041, Russia; Krasnoyarsk Scientific Centre, SB RAS 50 Akademgorodok, Krasnoyarsk, 660036, Russia
Keywords
capillary electrophoresis; betulonic acid; hydroxypropyl-γ-cyclodextrin; inclusion complexes; solubility
Abstract

Solubility of betulonic acid in 40 mM hydroxypropyl-γ-cyclodextrin solution was studied by capillary electrophoresis. It was shown that the equilibrium of complexation reaction between betulonic acid and hydroxypropyl-γ-cyclodextrin was established for three days. The oxidation of betulonic acid by atmospheric oxygen was shown not to occur during the long stirring. The solubility of betulonic acid in 40 mM aqueous cyclodextrin solution was 410±20 mg/l.

Pages
171-176
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/26411