Journal of Siberian Federal University. Biology / Microbial Barrier Property and Blood Compatibility Studies of Electrospun Poly-ƹ-Caprolactone/ Zinc Oxide Nanocomposite Scaffolds

Full text (.pdf)
Issue
Journal of Siberian Federal University. Biology. 2017 10 (2)
Authors
Augustine, Robin; Kalarikkal, Nandakumar; Thomas, Sabu
Contact information
Augustine, Robin: International and Inter University Centre for Nanoscience and Nanotechnology Mahatma Gandhi University Kottayam 686 560, Kerala, India; School of Nano Science and Technology National Institute of Technology Calicut Kozhikode, Calicut 673 601, Kerala, India; ; Kalarikkal, Nandakumar: International and Inter University Centre for Nanoscience and Nanotechnology Mahatma Gandhi University Kottayam 686 560, Kerala, India; School of Pure and Applied Physics Mahatma Gandhi University Kottayam 686 560, Kerala, India; Thomas, Sabu: International and Inter University Centre for Nanoscience and Nanotechnology Mahatma Gandhi University Kottayam 686 560, Kerala, India; School of Chemical Sciences Mahatma Gandhi University Kottayam 686 560, Kerala, India;
Keywords
poly-ƹ-caprolactone; zinc oxide; tissue engineering; scaffolds; blood compatibility; microbial barrier property
Abstract

Electrospun poly-ƹ-caprolactone/zinc oxide (PCL/ZnO) nanocomposite scaffolds were reported for tissue engineering and wound healing applications. Wound coverage materials should have good barrier property against invading microbes. Since wound coverage materials and tissue engineering scaffolds are in direct contact with blood, such materials should be blood compatible. Thus, blood compatibility of the fabricated scaffolds has been tested by RBC and WBC aggregation studies. Hemolysis assay and platelet activation study were also carried out. This study is promising in the sense that the fabricated scaffolds showed excellent microbial barrier property and were highly compatible with RBC and WBC and did not induce haemolysis. However, need to be vigilant regarding the possible platelet aggregation that can happen at higher concentrations of ZnO nanoparticles

Pages
226-236
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/33372

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