Siberian Federal University

Issue

Journal of Siberian Federal University. Biology. 2012 5 (4)

Authors

Vinnik, Yuri S.; Markelova, Nadezhda M.; Miller, Sergey V.; Vasilyenya, Ekaterina S.; Cherepanova, Elena S.; Yakovlev, Andrey V.; Repina, Elena V.; Shageev, Andrey A.; Shishatskaya, Ekaterina I.

Contact information

Vinnik, Yuri S.: V.F. Voino-Yasenetsky Krasnoyarsk State Medical University , 1 Partizan Zheleznyak Str., Krasnoyarsk, 660022 Russia; Markelova, Nadezhda M.: V.F. Voino-Yasenetsky Krasnoyarsk State Medical University , 1 Partizan Zheleznyak Str., Krasnoyarsk, 660022 Russia , e-mail: ; Miller, Sergey V.: Municipal Clinical Hospital No. 7 , 4 Pavlov Str., Krasnoyarsk, 660003 Russia; Vasilyenya, Ekaterina S.: V.F. Voino-Yasenetsky Krasnoyarsk State Medical University , 1 Partizan Zheleznyak Str., Krasnoyarsk, 660022 Russia; Cherepanova, Elena S.: V.F. Voino-Yasenetsky Krasnoyarsk State Medical University , 1 Partizan Zheleznyak Str., Krasnoyarsk, 660022 Russia; Yakovlev, Andrey V.: Municipal Clinical Hospital No. 4 , 71 Kutuzov Str., Krasnoyarsk, 660094 Russia; Repina, Elena V.: V.F. Voino-Yasenetsky Krasnoyarsk State Medical University , 1 Partizan Zheleznyak Str., Krasnoyarsk, 660022 Russia; Shageev, Andrey A.: V.F. Voino-Yasenetsky Krasnoyarsk State Medical University , 1 Partizan Zheleznyak Str., Krasnoyarsk, 660022 Russia; Shishatskaya, Ekaterina I.: Siberian Federal University; Institute of Biophysics SB RAS , 79 Svobodnyi, Krasnoyarsk, 660041 Russia; 50-50 Akademgorodok, Krasnoyarsk, 660036 Russia

Keywords

polyhydroxyalkanoates; biodegradable polymers; applications; reconstructive surgery

Abstract

The paper reports analysis of results of the first limited clinical trials of high technology medical devices prepared using polyhydroxyalkanoates (PHAs) – degradable microbial biopolymers: PHA coated mesh stents for surgical repair of inguinal hernia, endobiliary stents for treatment of the patients with obstructive jaundice caused by extrahepatic biliary obstruction due to different reasons, and biodegradable monofilament sutures for closing operative wounds on the abdominal wall. The devices were compared with their commercial Russian and foreign analogs widely used clinically. The choice of the device influenced the incidence of early and delayed postsurgical complications and laboratory and clinical parameters. The study proves the suitability of PHA-based devices for reconstructive surgery.

Pages

387-403

Paper at repository of SibFU

https://elib.sfu-kras.ru/handle/2311/9555

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).