Journal of Siberian Federal University. Chemistry / The mechanocomposite of betulin diacetate and its Antitumor Activity

Full text (.pdf)
Issue
Journal of Siberian Federal University. Chemistry. 2013 6 (2)
Authors
Kuznetsova, Svetlana A.; Shakhtshneider, Tatyana P.; Mikhailenko, Mikhail A.; Malyar, Yuriy N.; Zamay, Anna S.; Boldyrev, Vladimir V.
Contact information
Kuznetsova, Svetlana A.: Institute of Chemistry and Chemical Technology SB RAS, 50/24, Akademgorodok, Krasnoyarsk, 660036 Russia; Siberian Federal University, 79 Svobodny, Krasnoyarsk,660041 Russia;; Shakhtshneider, Tatyana P.: Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze St., Novosibirsk, 630128 Russia; Research and Educational Center “Molecular Design and Ecologically Safe Technologies”, 2 Pirogov St., Ch. Building, 125, Novosibirsk, 630090 Russia;; Mikhailenko, Mikhail A.: Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze St., Novosibirsk, 630128 Russia; Research and Educational Center “Molecular Design and Ecologically Safe Technologies”, 2 Pirogov St., Ch. Building, 125, Novosibirsk, 630090 Russia; e-mail: ; Malyar, Yuriy N.: Institute of Chemistry and Chemical Technology SB RAS, 50/24, Akademgorodok, Krasnoyarsk, 660036 Russia;; Zamay, Anna S.: Institute of Chemistry and Chemical Technology SB RAS, 50/24, Akademgorodok, Krasnoyarsk, 660036 Russia; Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky, 1 Partizan Jeleznyak St., Krasnoyarsk, 660022 Russia;; Boldyrev, Vladimir V.: Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze St., Novosibirsk, 630128 Russia; Research and Educational Center “Molecular Design and Ecologically Safe Technologies”, 2 Pirogov St., Ch. Building, 125, Novosibirsk, 630090 Russia;
Keywords
betulin diacetate; arabinogalactan; mechanochemical treatment; dissolution; gel-penetrating chromatography; antitumor properties
Abstract

Using gel-penetrating chromatography, it has been shown that mechanochemical treatment of a mixture of arabinogalactan (AG) with betulin diacetate (DAB) in a ball mill led to change of the molecular weight distribution (MWD) of AG. The presence of DAB in the mixture promoted restoration of MWD after dissolving the mechanically activated mixture in water and solvent evaporation. The formation of intermolecular complex DAB with AG at dissolution of initial and mechanically activated mixtures in water was suggested. It was shown that the mechanocomposites DAB with AG had the ability to induce cells in ascites Ehrlich carcinoma cell elimination processes mediated disturbance of ion homeostasis.

Pages
192-202
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/9824