Journal of Siberian Federal University. Biology / The Effect of Different Levels of Chromium Chloride Supplementation on Antioxidant Defense System in the Rats

Full text (.pdf)
Issue
Journal of Siberian Federal University. Biology. 2013 6 (3)
Authors
Iskra, Ruslana Ja.
Contact information
Iskra, Ruslana Ja.:Institute of Animal Biology NAAS, 38 V. Stus Str., Lvov, 79034 Ukraine
Keywords
chromium; lipid peroxidation; superoxide dismutase; catalase; glutathione peroxidase; glutathione reductase; rats
Abstract

The study was conducted to evaluate the effect of different amounts (0, 70, 140 μg Cr/L of drinking water) of chromium chloride (CrCl3 · 6H2O) on the antioxidant system performance in rats. As a result, a higher content of lipid peroxidation products was established in blood of the tested rats that received no chromium (0 μg Cr/L) compared with animals which obtained chromium chloride solution in their ration. Chromium chloride taken by rats at a dose of 70 μg Cr/L decreased the content of thiobarbituric acid-reactive substances by 20.3 %, whereas the dose of 140 μg Cr/L decreased concentrations of hydroperoxides of lipids by 22.1 % compared with animals that received no chromium. Adding of chromium to drinking water at a dose of 70 and 140 μg Cr/L decreased activity of superoxide dismutase in erythrocytes of blood by 38.6 % and 62.0 %, while catalase activity increased by 26.7 % and 46.2 % and glutathione peroxidase by 12.4 % and 21.0 % respectively in comparison with animals of control group. Concluded, supplying of rat’s organism with chromium in doses 70 and 140 μg Cr/L of drinking water promotes inhibition of lipid peroxidation and enhancing of enzymatic antioxidant level

Pages
246-256
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/10201

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