Journal of Siberian Federal University. Chemistry / Ribose Moieties Acylation and Characterization of Some Cytidine Analogs

Full text (.pdf)
Issue
Journal of Siberian Federal University. Chemistry. 2020 13 (4)
Authors
Rana, Kazi M.; Ferdous, Jannatul; Hosen, Anowar; Kawsar, M.A.
Contact information
Rana, Kazi M.L.: Laboratory of Carbohydrate and Nucleoside Chemistry (LCNC) Department of Chemistry, Faculty of Science University of Chittagong Chittagong, Bangladesh;; Ferdous, Jannatul: Laboratory of Carbohydrate and Nucleoside Chemistry (LCNC) Department of Chemistry, Faculty of Science University of Chittagong Chittagong, Bangladesh; Hosen, Anowar: Centre for Advanced Research in Sciences University of Dhaka Dhaka, Bangladesh; Kawsar, M.A.: Laboratory of Carbohydrate and Nucleoside Chemistry (LCNC) Department of Chemistry, Faculty of Science University of Chittagong Chittagong, Bangladesh
Keywords
ribose; acylation; analogs; cytidine; spectroscopy
Abstract

Modification of naturally occurring nucleosides is an important area in the search for new agents with therapeutic potential. In this study, nucleoside molecules, that is, cytidine analogs bearing ribose moieties were successfully synthesized to obtain 5´-O-acyl cytidine (2), which in turn was converted into 2´,3´-di-O-acyl cytidine (3–7) through direct acylation. Similarly, several cytidine analogs (8–15) were formed using the aforementioned technique. Physicochemical properties and spectroscopic methods were used to characterize the newly synthesized cytidine analogs. X-ray powder diffraction was employed for quantitatively identifying crystalline compounds. Hence, these synthesized derivatives can be used as potential antimicrobial agents and promising drug candidates

Pages
465–478
DOI
10.17516/1998-2836-0199
Paper at repository of SibFU
https://elib.sfu-kras.ru/handle/2311/137871