Siberian Federal University 
- Issue
- Journal of Siberian Federal University. Chemistry. 2024 17 (3)
- Authors
- Levdansky, Vladimir A.; Ivanenko, Timur Yu.; Levdansky, Alexander V.
- Contact information
- Levdansky, Vladimir A.: Institute of Chemistry and Chemical Technology FRC KSC SB RAS Krasnoyarsk, Russian Federation; Ivanenko, Timur Yu.: Institute of Chemistry and Chemical Technology FRC KSC SB RAS Krasnoyarsk, Russian Federation; Levdansky, Alexander V.: Institute of Chemistry and Chemical Technology FRC KSC SB RAS Krasnoyarsk, Russian Federation;
- Keywords
- allobetulin; sulfation; sulfamic acid; urea; 1,4-dioxane; N, N‑dimethylformamide; allobetulin 3-sulfate
- Abstract
Sulfuric acid esters of betulin and its numerous derivatives are of interest to the chemical and pharmaceutical industry as complement inhibitors. The development of new efficient methods for the synthesis of sulfuric acid esters of betulin and its derivatives is an actual task. The sulfation of allobetulin with sulfamic acid in the presence of urea in a medium of 1,4-dioxane and N, N‑dimethylformamide was studied for the first time. It was found that the reaction proceeds in a homogeneous medium at a temperature of 70–75 °C in 3–4 hours with the formation of allobetulin 3-sulfate. The structure of allobetulin 3-sulfate was confirmed by FTIR and NMR spectroscopy, and its composition was confirmed by elemental analysis
- Pages
- 448–456
- EDN
- XFJGLD
- Paper at repository of SibFU
- https://elib.sfu-kras.ru/handle/2311/153823
Journal of Siberian Federal University. Chemistry / Sulfation of Allobetulin with Sulfamic Acid in N, N‑dimethylformamide and 1,4-dioxane
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