Siberian Federal University 
- Issue
- Journal of Siberian Federal University. Chemistry. 2025 18 (1)
- Authors
- Bobrov, Pavel S.; Olchev, Daniil A.; Vishnyakova, Ekaterina E.; Suboch, Georgii A.
- Contact information
- Bobrov, Pavel S. : Reshetnev Siberian State University of Science and Technology Krasnoyarsk, Russian Federation; ; Olchev, Daniil A.: Reshetnev Siberian State University of Science and Technology Krasnoyarsk, Russian Federation; Vishnyakova, Ekaterina E. : Reshetnev Siberian State University of Science and Technology Krasnoyarsk, Russian Federation; Suboch, Georgii A.: Reshetnev Siberian State University of Science and Technology Krasnoyarsk, Russian Federation
- Keywords
- aminopyrazole; nitrosoaniline; nitrosopyrazole; cyclocondensation; luorine-substituted; diketone
- Abstract
We demonstrated the first synthesis of 2-hydroxyimino-1-(4-fluorophenyl)butane-1,3-dione by nitrosation of 1-(4-fluorophenyl)butane-1,3-dione with sodium nitrite in acetic acid. The three-component reaction of 2-hydroxyamino-1-(4-fluorophenyl)butane-1,3-dione with acetone and aliphatic dialkylamines (diethylamine or diethanolamine) leads to new N, N-dialkyl-3-methyl-4-nitroso-5-(4-fluorophenyl) anilines. Cyclocondensation of 2-hydroxyimino-1-(4-fluorophenyl)butane-1,3-dione with hydrazine hydrate leads to 3-methyl-4-nitroso-5-(4-fluorophenyl)-1H-pyrazole. Reduction of nitrosopyrazole gives the corresponding fluoro- substituted aminopyrazole. The synthesized compounds were characterized by IR, NMR, UV–Vis, and MS
- Pages
- 34–40
- EDN
- BUBZGG
- Paper at repository of SibFU
- https://elib.sfu-kras.ru/handle/2311/155023
Journal of Siberian Federal University. Chemistry / Synthesis of Novel 4-Fluorophenyl- Substituted Carbocyclic and Heterocyclic Compounds
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