Сибирский федеральный университет

Синтезированы новые соединения одного из важных антибактериальных лекарств энрофлоксацина (C₁₉H₂₂FN₃O₃ − 1-циклопропил-7-(4-этилпиперазин-1-ил)-6-фторо-4-оксо-1,4- дигидрохинолин-3-карбоновая кислота, EnrH) с кислотами и тетрагалогенидными анионами d-элементов. Получены соединения: EnrH₂ ⁺X^-nH₂O (X = Cl, HSO₄, n = 1; X = Br, I, NO₃, H₂PO₄, ReO₄, n = 0), 2EnrH₂ ⁺C₂O₄ ^2-.H₂O, EnrH₃ ²⁺2Br^-, (EnrH₂ ⁺)₂[MCl₄]^2- (M = Zn, Cd, Hg), EnrH₃ ²⁺[MCl₄]^2- (M = Zn, Cd, Hg, Co, Cu) и EnrH₃ ²⁺[MBr₄]^2-.nH₂O (M = Cu, n = 2; M = Cd, n = 1; M = Zn, Hg, Co, n = 0). Определены их кристаллографические параметры и изучена термическая устойчивость.

The new compounds of significant antibacterial drug enrofloxacin (C₁₉H₂₂FN₃O₃ - 1-cyclopropyl- 7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, EnrH) with the acids and the tetrahalogenate anions of d-elements have been synthesized. The compounds EnrH₂ ⁺X^-nH₂O (X = Cl, HSO₄, n = 1; X = Br, I, NO₃, H₂PO₄, ReO₄, n = 0), 2EnrH₂ ⁺C₂O₄ ^2-.H₂O, EnrH₃ ²⁺2Br^-, (EnrH₂ ⁺)₂[MCl₄]^2- (M = Zn, Cd, Hg), EnrH₃ ²⁺[MCl₄]^2- (M = Zn, Cd, Hg, Co, Cu) и EnrH₃ ²⁺[MBr₄]^2-.nH₂O (M = Cu, n = 2; M = Cd, n = 1; M = Zn, Hg, Co, n = 0) have been prepared. Their crystallographic parameters and thermal properties have been studied.